Effect of a Single Pre-Operative Dose of Dexmedotomidine Versus Fentanyl on Anesthetic Requirement and Peri- Operative Hemodynamic Stress Response

Background: Dexmedetomidine has sympatholytic, ant nociceptive, sedative, and anti-sialagogue properties without causing respiratory depression. Dexmedetomidine is the active d-isomer of medetomidine, that is a selective and specific α2-adrenoceptor agonist. It acts by the central sympatholytic action. So it provides haemodynamic stability. It has both analgesic as well as anaesthetic sparing property. Dexmedetomidine is also an effective sedative. Methods: Study Population:- Two groups were included in this study.49 cases were included in group II & 50 cases were included in group II.The duration of study was over a period of 6 month.This study was conducted in the Department of Anesthesia in Carrier Institute of Medical Sciences, Lucknow. Results: This result revealed that adverse effect of bradycardia was seen only in one patient. None of the patients was sedated after discontinuation of anesthesia. Conclusion: This study concludes that, during laryngoscopy and in the perioperative period, a single pre-operative dose of Dexmedetomidine provides better hemodynamic stability in comparison to Fentanyl by attenuation of sympathoadrenal response.

Comparison of Dexmedetomidine as an Adjuvant to Ropivacaine Vs. Ropivacaine Alone in Lower Abdominal & Lower Limb Surgeries

Introduction: For lower abdominal and lower limb surgeries,epidural anesthesia technique of central neuraxial blockade isin used very commonly as this technique avoids theshortcomings and drawbacks of general anesthesia like airwaymanipulation and poly-pharmacy along with other untowardeffects like postoperative nausea and vomiting while ruling outneed for additional intravenous analgesics.Methodology: In our study two groups were included that wasgroup R and group RD. 50 cases were included in in eachgroups. This study was conducted in the Department ofAnesthesia, Carrier Institute of Medical Sciences & Hospital,Lucknow, U.P., India.Study Duration: The duration of study was over a period of sixmonths.Result: In our study two groups were included that was groupR and group RD. 50 cases were included in in each groups.The mean duration of motor blockade is 149.00±14.21mins ingroup R and 233.70±15.26 minutes in group RD; alsosignificant difference between the group (p=0.001).Conclusion: This study suggested that Dexmedetomidinewhen added to Ropivacaine produces profound synergisticeffect and prolongs motor and sensory blockade.